This is an easy one! My favourite character from any game is Manny Calavera from Grim Fandango. Manny begins the game as a grim reaper, working for the Department of Death to pay off his debts before moving on to the afterlife. At the start of the game, his life seems mundane and he is focused on serving his time with as little incident as possible.
As the game progresses and a mystery unfolds before him, he evolves, developing into a hero, in the style of old film noire. His quick-wit and sarcasm make him a funny character, but he is also both competitive and vulnerable, making him quite a relatable character. Manny’s voice actor is Tony Plana who perfectly captures this character.
Here are a couple of trailers for both the remastering of Grim Fandango and the original edition: